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曾发现心房舒张条件下释放的ANP(atrial natriuretic peptide)具有促尿钠排法的效应.它最突出地表现在对抗肾素-血管紧张肽-醛固酮系统:抑制肾素生成,抑制醛固酮释放,还可能特异性地抑制血管紧张肽Ⅱ对血管及肾上腺皮质的活性,加速自由水的清除及抑制AVP(精氨酸血管加压素,areinine Vasopressin)的释放.一些离体实验已经证明ANP对基础水平的AVP产生多种效果,证明ANP对KCl、血管紧张肽Ⅱ和渗透压刺激下的AVP释放有抑制作用.在动物体内,使用静脉注射和脑室内注射两方法,至少在药理剂量,证明对渗透压和出血诱导的AVP产生抑制效应.
It has been found that atrial natriuretic peptide (ANP) released under atrial diastolic conditions has the effect of natriuretic peptide production, most notably against the renin-angiotensin-aldosterone system: inhibition of renin production, inhibition of aldosterone release, and possibly Specifically inhibits the activity of angiotensin II on blood vessels and adrenal cortices, accelerates the clearance of free water and inhibits the release of AVP (areinine Vasopressin). Some in vitro experiments have demonstrated that ANP has a significant effect on basal levels of AVP produced a variety of effects, demonstrating that ANP inhibited the release of AVP under KCl, angiotensin II and osmotic stimulation.In vivo, intravenous and intracerebroventricular injection of two methods, at least in pharmacological doses, prove that the osmotic pressure And hemorrhage-induced AVP production inhibitory effect.