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目的探究经直肠超声引导下前列腺穿刺活检的临床病理特点。方法 105例前列腺疾病患者,对其进行直肠超声引导下前列腺穿刺活检,对患者的临床病理特点进行分析。结果 105例患者中,检测出前列腺癌患者41例,占39.05%;前列腺上皮内瘤变1级3例,占2.86%;前列腺良性增生52例,占49.52%;前列腺不典型腺瘤样增长5例,占4.76%;慢性前列腺炎症4例,占3.81%。前列腺癌腺体结构复杂多样,采用Gleason评分法进行分级,本组41例前列腺癌患者中,<5分的高分化癌6例,6~7分中分化癌23例,≥8分低分化癌12例。免疫组化结果中,前列腺特异性抗原(PSA)、α-甲酰基辅酶A消旋酶(P504S)表达为阳性,细胞角蛋白(CK)、P63、34βE12表达为阴性。结论经直肠超声引导下前列腺穿刺活检对前列腺癌的诊断具有重要意义,具有较高的安全性与准确性,是有效的诊断方法。通过对临床病理特点进行分析,可以进行综合判断,并借助免疫组化检查,明显提高诊断的准确率。
Objective To investigate the clinicopathological features of prostate biopsy guided by transrectal ultrasound. Methods A total of 105 patients with prostatic diseases underwent transrectal ultrasound-guided prostatic biopsy. The clinicopathological features of the patients were analyzed. Results Of 105 patients, 41 cases of prostate cancer were detected, accounting for 39.05%; 3 cases of grade 1 prostate cancer, accounting for 2.86%; benign prostatic hyperplasia in 52 cases, accounting for 49.52%; prostate adenocarcinoma-like adenocarcinoma-like growth of 5 Cases, accounting for 4.76%; 4 cases of chronic prostatitis, accounting for 3.81%. Prostate gland complex and diverse structure, using Gleason score grading, the group of 41 patients with prostate cancer, <5 points of well-differentiated carcinoma in 6 cases, 6 to 7 points in the differentiation of cancer in 23 cases, ≥ 8 points of poorly differentiated carcinoma 12 cases. Immunohistochemical results showed that prostate-specific antigen (PSA), α-formyl-CoA racemase (P504S) were positive, cytokeratin (CK) and P63, 34βE12 were negative. Conclusion Transrectal ultrasound-guided prostate biopsy is of great significance for the diagnosis of prostate cancer, with high safety and accuracy. It is an effective diagnostic method. Through the analysis of clinical and pathological features, can make a comprehensive assessment, and by immunohistochemical examination, significantly improve the diagnostic accuracy.