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最近9年来,我有机会获得人白细胞干扰素的供应,来进行临床应用的研究。今天我愿意和大家分享我们所取得的某些经验。一、干扰素的特性干扰素是一种糖蛋白,它具有极为强大的抗病毒活性。现在人和小白鼠的干扰素已被提纯,而人干扰素的部分核酸顺序已被确定,纯化干扰素的抗病毒活性可达10~9单位/毫克蛋白以上。每个细胞只需要一个分子的干扰素,即可达到抵抗病毒感染的状态。它是一种广谱制剂,既可对抗核糖核酸(RNA)和脱氧核糖核酸(DNA)病毒,也能抑制更复杂的细胞内寄生物。所有的脊椎动物都能产生干扰素。除了细胞内的病原体可以诱生干扰素之外,一些药物也可以诱生干扰素。作为一种淋巴因子,干扰素也是细胞免疫反应的一个组成部分。
For the last 9 years, I have had the opportunity to get the supply of human leukocyte interferon for clinical research. Today I would like to share with you some of the experiences we have gained. First, the characteristics of interferon Interferon is a glycoprotein, it has a very powerful antiviral activity. Now human and mouse interferon has been purified, and human interferon part of the nucleic acid sequence has been identified, the purified interferon antiviral activity up to 10 ~ 9 units / mg protein. Each cell requires only one molecule of interferon, you can reach the state of resistance to viral infection. It is a broad-spectrum formulation that works both against RNA and DNA viruses and inhibits more complex cellular parasites. All vertebrates produce interferon. In addition to intracellular pathogens can induce interferon, some drugs can also induce interferon. As a lymphokine, interferons are also an integral part of the cellular immune response.