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变异链球菌是龋病的主要病原菌之一,变异链球菌表面蛋白对细菌在牙面的初始黏附及菌体之间的聚集起重要作用。有研究证实表面蛋白抗原Ⅰ/Ⅱ的阳性免疫与抗蛋白P1单克隆抗体的阴性免疫都能抑制变异链球菌致龋,因此表面蛋白P1已被看作龋病疫苗开发的潜在抗原[1]。该文就P1结构中的脯氨酸富集区(P区)、丙氨酸富集区(A区)及两者之间的相互作用对P1的免疫原性、稳定性和表面表达等方面的影响作一综述。
Streptococcus mutans is one of the main pathogens of dental caries. Streptococcus mutans surface protein plays an important role in the initial adhesion of bacteria to bacteria and the aggregation between the bacteria. Studies have shown that both surface immunoprecipitation of surface antigen I / II and negative immunization of anti-protein P1 monoclonal antibodies can inhibit S. mutans-induced cariogenicity. Therefore, surface protein P1 has been considered as a potential antigen developed by cariogenic vaccines [1]. In this paper, we investigated the immunogenicity, stability and surface expression of P1 related to the interaction between proline-rich region (P region) and alanine-rich region (region A) in P1 structure The impact of a review.