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目的:探讨抗菌药物不同给药时间对行手工刮治重度慢性牙周炎短期疗效与牙周膜细胞增生的影响。方法:选择2015年1月至12月在我院接受治疗的90例重度慢性牙周炎患者作为本研究对象,并将其随机分成A、B和C组,每组各30例。A组患者在首次接受龈下刮治治疗开始之前的0.5~1 h之内给予甲硝唑片联合阿莫西林胶囊口服治疗,B组患者在刮治治疗后给予甲硝唑片联合阿莫西林胶囊口服治疗,C组患者给予口服安慰剂。分别检查并比较3组患者治疗前和治疗后2个月的平均探诊深度(PD)、平均邻面探诊深度(p PD)、探诊出血位点的百分数(BOP%)、探诊深度大于5 mm位点百分数(PD>5 mm%)、邻面探诊深度大于5 mm位点百分数(p PD>5 mm%)及平均出血指数(BI)。结果:各组患者治疗后PD、p PD、BOP%、PD>5 mm%、p PD>5 mm%及BI改善均十分明显,差异有统计学意义(P<0.05);A组患者治疗后PD和p PD显著低于B组和C组,差异有统计学意义(P<0.05);B组患者PD和p PD显著低于C组,但差异无统计学意义(P>0.05);此外,3组患者治疗后BOP%、PD>5 mm%、p PD>5 mm%及BI等指标之间比较,差异无统计学意义(F=3.015、2.327、2.983、1.861,P>0.05);A组患者牙周膜细胞增殖情况明显优于B组和C组,差异具有统计学意义(P<0.05)。结论:重度慢性牙周炎患者刮治同期给予抗菌药物治疗,其临床短期疗效明显优于刮治后再行给药治疗和单纯行刮治治疗。
Objective: To investigate the effect of different administration time of antimicrobial agents on the short-term efficacy of hand-scraping and treating severe chronic periodontitis and periodontal ligament cell proliferation. METHODS: Ninety patients with severe chronic periodontitis who were treated in our hospital from January to December 2015 were selected as the study subjects and randomly divided into groups A, B and C, with 30 cases in each group. Patients in group A were treated with metronidazole tablets combined with amoxicillin capsules within 0.5-1 h before the first subgingival cure treatment. Patients in group B were treated with metronidazole tablets combined with amoxicillin Capsule oral treatment, C group patients were given oral placebo. The average probing depth (PD), average proximal probing depth (p PD), the percentage of visiting bleeding site (BOP%), the probing depth before treatment and 2 months after treatment were examined and compared among the three groups The percentage of sites with a depth of more than 5 mm (PD> 5 mm%), the probing depth of the adjacent site was greater than 5 mm (p PD> 5 mm%) and the average bleeding index (BI). Results: After treatment, the PD, p PD, BOP%, PD> 5 mm%, p PD> 5 mm% and BI improved obviously in all groups, with significant difference (P <0.05) PD and p PD were significantly lower than those in group B and C (P <0.05); PD and p PD in group B were significantly lower than those in group C, but the difference was not statistically significant (P> 0.05); in addition There was no significant difference in BOP%, PD> 5 mm%, p PD> 5 mm% and BI between the three groups after treatment (F = 3.015,2.327,2.983,1.861, P> 0.05). The proliferation of periodontal ligament cells in group A was significantly better than that in group B and C (P <0.05). Conclusion: Patients with severe chronic periodontitis should be treated with antimicrobial drugs at the same time. The short-term clinical efficacy is superior to the cure after cure and the cure by simple cure.