用广州血管圆线虫幼虫感染大鼠、、金色仓鼠及小鼠,结果52.1％的大鼠在感染后第24～35天死亡。主要由于幼龄成虫从脑向肺转移引起脑血管损伤,造成严重出血,加上虫体对脑组织的直接损伤。感染后第31天起,虫卵沉着于肺组织,第36天起幼虫移行引起肺泡毛细血管的损伤和机休反应,导致周围炎症细胞浸润和纤维增生,病变广泛时可引起呼吸衰竭,并发感染加速其死亡。 Infected with C. elegans larvae in Guangzhou, golden hamsters and mice, 52.1% of the rats died on day 24 to 35 after infection. Mainly due to young adults from brain to lung metastasis caused by cerebrovascular injury, resulting in severe bleeding, coupled with parasites of brain tissue directly damaged. On the 31st day after infection, the eggs settled in the lung tissue. On the 36th day, the larva migrated and caused the damage of the alveolar capillaries and the motor failure reaction, resulting in the infiltration of inflammatory cells and fibrosis in the surrounding area. When the lesions were extensive, they could cause respiratory failure and complicated infection Accelerate its death.