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目的:观察通肺饮超声雾化吸入联合化疗对非小细胞肺癌的临床疗效,并初步探讨其作用机理。方法:采用随机法将90例非小细胞肺癌痰瘀互结型患者分为治疗组(化疗加通肺饮雾化)30例、对照组(化疗加通肺饮口服)30例和空白组(单纯化疗)30例,比较3组临床完成情况、近期客观疗效、治疗前后临床症状、生活质量卡氏评分、体重、免疫功能(NK细胞)的变化和毒副反应情况。结果:治疗组和对照组可较好改善部分临床症状,稳定并增加体重,提高患者生存质量,保护机体免疫功能,减轻化疗毒副反应;但在减小和稳定病灶方面与单纯化疗组相比无显著性差异(P>0.05);治疗组和对照组相比,雾化吸入法通过呼吸道给药,可直接作用于病灶,易于被患者接受(P<0.05)。结论:肺饮超声雾化吸入对非小细胞肺癌有较好的临床效果。
Objective: To observe the clinical effect of Tongfei Decoction combined with atomizing inhalation and chemotherapy on non-small cell lung cancer and to explore its mechanism. Methods: Ninety non-small cell lung cancer patients with phlegm and blood stasis type were randomly divided into treatment group (Chemotherapy plus Tongfei Yin aerosolized) 30 cases, control group (chemotherapy plus Tongfei Yin oral administration) 30 cases and blank group Simple chemotherapy) .30 cases were divided into three groups: clinical completion, objective curative effect, clinical symptoms before and after treatment, Karnofsky’s scores of quality of life, body weight, changes of immune function (NK cells) and adverse reactions. Results: The treatment group and the control group could improve some clinical symptoms, stabilize and increase the body weight, improve the quality of life, protect the immune function and reduce the side effects of chemotherapy. Compared with the chemotherapy alone group, There was no significant difference between the two groups (P> 0.05). Compared with the control group, the inhalation therapy by inhalation could be directly applied to the lesion and easily accepted by the patients (P <0.05). Conclusion: Pulmonary drinking ultrasound nebulization has a good clinical effect on non-small cell lung cancer.