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目的研究酮洛芬的脊髓镇痛作用及作用机制。方法采用温浴法、热板法观察动物痛阈变化。结果鞘内注射（ｉｔｈ）酮洛芬１．６～３．２ｍｇ·ｋｇ－１具有明显镇痛作用，全身用药需１６ｍｇ·ｋｇ－１才具有同等镇痛效应。ｉｔｈ与ｉｐ药物有效剂量比为１∶１０。ｉｔｈ用药，作用可被ｉｐ利血平、ｓｃ哌唑嗪、育亨宾阻滞。结论酮洛芬具有脊髓镇痛作用，其机制与ＮＥ－α受体系统介导的内源性镇痛系统密切相关
Objective To study the analgesic effect and mechanism of ketoprofen on spinal cord. Methods The changes of pain threshold were observed by hot bath method and hot plate method. Intrathecal injection of (ith) ketoprofen 1.6 ~ 3.2mg · kg-1 has obvious analgesic effect, systemic medication need 16mg · kg-1 to have the same analgesic effect. ith and ip drug effective dose ratio of 1:10. ith medication, the role can be ip reserpine, sc prazosin, yohimbe block. Conclusion Ketoprofen has spinal cord analgesia and its mechanism is closely related to the NE-α receptor-mediated endogenous analgesic system