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卵巢癌二次探查阳性者预后不良。这类病人应该采用何种方法治疗?二线化疗效果不好,全腹照射只对微小残留病灶有效。腹腔化疗和免疫治疗是较新方法,有效率为30～45%。梅法兰(melphalan)是治疗上皮性卵巢癌最有效的一种烷化剂,该药疗效回剂量有关,其主要毒性是在造血系统,而卵巢癌转移至骨髓少见。作者1984年起治疗14例二次探查阳性者,其中浆液性8例,Ⅳ期1例,粘液性2例,内膜癌1例。Ⅲ期12例,Ⅳ期1例,Ⅱ期术后复发1例。12
Ovarian cancer secondary exploration positive prognosis is poor. Such patients should be treated by what method? Second-line chemotherapy is not effective, full abdominal irradiation is valid for minimal residual lesions. Intraperitoneal chemotherapy and immunotherapy is a relatively new method, the effective rate of 30 to 45%. Melphalan is the most effective alkylating agent in the treatment of epithelial ovarian cancer. The efficacy of this drug is back to the dose, its main toxicity is in the hematopoietic system, and metastasis of ovarian cancer to the bone marrow is uncommon. The authors treated 14 cases of secondary exploration since 1984, of which serosal in 8 cases, Ⅳ in 1 case, 2 cases of mucinous, 1 case of endometrial cancer. 12 cases of stage Ⅲ, 1 case of stage Ⅳ, and 1 case of stage Ⅱ recurrence. 12