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目的:探讨丙基硫氧嘧啶(PTU)与甲巯咪唑(MMI)对治疗妊娠合并甲状腺功能亢进的疗效、妊娠结局以及对胎儿的影响。方法:选择2013年3月至2015年3月于我院确诊并接受治疗的90例妊娠合并甲状腺功能亢进孕妇作为研究试验对象,按是否服用PTU和MMI治疗分为A、B、C组,A组采用口服PTU进行治疗,B组采用口服甲巯咪唑进行治疗,C组未服用抗甲状腺药物。对三组患者的甲状腺功能、妊娠结局以及新生儿平均体重和1min Apgar评分进行数据分析。结果:A、B组患者的游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)以及血清促甲状腺激素(TSH)水平均显著低于C组,A组患者的FT3、FT4和TSH的水平低于B组,数据之间具有显著性差异(P<0.05);A、B组妊娠结局好于C组,数据之间具有显著性差异(P<0.05),A组与B组相关指标无显著性差异(P>0.05);A、B组患者胎儿的平均体重高于C组,并且1min Apgar评分也均高于C组,差异具有显著性(P<0.05)。A组与B组在胎儿体重方面无显著性差异(P>0.05),但在1min Apgar评分上表现出显著性差异(P<0.05)。结论:丙基硫氧嘧啶与甲巯咪唑均可以显著改善妊娠合并甲状腺功能亢进患者的甲状腺功能,改善妊娠结局,并可以增加胎儿体重,提高Apgar评分。
Objective: To investigate the efficacy of propylthiouracil (PTU) and methimazole (MMI) in the treatment of pregnancy complicated with hyperthyroidism, the outcome of pregnancy and its effect on the fetus. Methods: From March 2013 to March 2015 in our hospital diagnosed and treated 90 cases of pregnant women with hyperthyroidism as research subjects, according to whether to take PTU and MMI treatment is divided into A, B, C group, A Group treated with oral PTU, B group treated with oral methimazole, C group did not take anti-thyroid drugs. Thyroid function, pregnancy outcome, and mean neonatal weight and 1-minute Apgar scores were analyzed in three groups. Results: The levels of free triiodothyronine (FT3), free thyroid hormone (FT4) and serum thyrotropin (TSH) in group A and group B were significantly lower than those in group C, FT3, FT4 and TSH in group A (P <0.05). The pregnancy outcomes in groups A and B were better than those in group C (P <0.05), and there was a significant difference between groups A and B There was no significant difference between the two groups (P> 0.05). The average weight of fetuses in group A and group B was higher than that in group C, and Apgar scores at 1 minute were also higher than those in group C (P <0.05). There was no significant difference in fetal weight between group A and group B (P> 0.05), but there was a significant difference at 1 minute Apgar score (P <0.05). CONCLUSION: Both propylthiouracil and methimazole can significantly improve thyroid function, improve pregnancy outcomes, increase fetal weight and improve Apgar score in patients with hyperthyroidism during pregnancy.