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作者选择30例结核病患者(异烟肼慢乙酰化者18例,快乙酰化者12例),每日服用异烟肼300mg 和利福平12mg/kg 后,对其时间配对的唾液和血清标本进行异烟肼和利福平浓度的测定。结果表明,异烟肼弥散入唾液中的速度相当快,服药后第1小时大部分(13/18)患者出现高峰浓度,而且与血清浓度相似.根据唾液浓度推算的异烟肼高峰浓度,药物接触(Exposure)和排泄半衰期等药物动力学参数与根据血清浓度推算的相应值都很相近,其差别均无显著性(P>0.2),而利福平在唾液的浓度明显低于血清,服药后1、2、3、6、8小时,唾液中的几何平均浓度分别为0.2、0.6、0.8、0.5和0.4μg/ml,而血清中分别为3.4、6.5、7.0、4.7和3.0μg/ml。其平均
The authors selected 30 patients with tuberculosis (isoniazid slow acetylation in 18 cases, 12 cases of fast acetylation), daily isoniazid 300mg and rifampicin 12mg / kg, paired saliva and serum samples Isoniazid and rifampicin concentrations were determined. The results showed that isoniazid diffused into saliva very fast, most patients (13/18) in the first hour after taking the drug appeared peak concentration, and similar to the serum concentration.According to saliva concentration estimated isoniazid peak concentration, the drug Pharmacokinetic parameters such as exposure and half-life of excretion were similar to those estimated according to serum concentrations (P> 0.2), while the concentration of rifampicin in saliva was significantly lower than that in serum Geometrically mean concentrations in saliva were 0.2, 0.6, 0.8, 0.5 and 0.4 μg / ml at 1, 2, 3, 6, and 8 hours post- . Its average