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以58例健康人的均值作为正常对照,我们观察了49例烧伤病人血浆游离氨基酸浓度在伤后23天内的动态变化。49例10—98%TBSA/Ⅲ度0—87%烧伤病人的血浆游离氨基酸浓度的动态变化与烧伤面积和病情有关。例如:苏、丙、组、精、甘、脯氨酸浓度在10—29%TBSA/Ⅲ度0—11%烧伤后,在部伤或个别点明显低于健康人;随着面积的增大,其下降的程度加深或持续时间延长;烧伤面积达30%TBSA以上者,色、丝2种氨基酸的浓度也降低,也随面积的增大而下降更为明显或持续时间延长。苯丙氨酸浓度在小面积烧伤后就增高,随面积增大而上升更为明显或持续时间延长。枝链氨基酸在30%TBSA以上烧伤早期降低明显,以异亮氨酸为最明显。30%以上烧伤病人的血浆17种游离氨基酸的总浓度明显降低。这些血浆游离氨基酸浓度的变化与烧伤面积有关,说明在临床实际中是有意义的。
Taking the mean of 58 healthy people as the normal control, we observed the dynamic changes of plasma free amino acid concentration in 49 burn patients within 23 days after injury. 49 cases of 10-98% TBSA / Ⅲ degree 0-87% of patients with plasma free amino acid concentration dynamic changes in burn area and disease. For example, the concentration of proline in group C, SP, GAN and Pr was significantly lower than that in healthy people at 0-30% TBSA / Ⅲ degree 0-11% burns or at individual points; with the increase of area , The extent of its decline deepened or the duration of extension; burn area of more than 30% TBSA, color, silk two kinds of amino acid concentrations also decreased, but also with the area increased more obvious or prolonged duration. Phenylalanine concentration increased after a small area burn, with the area increased and the more obvious increase or duration. Branched-chain amino acids in the early burn at 30% TBSA decreased significantly, with isoleucine as the most obvious. The total concentration of 17 free amino acids in plasma of over 30% of burn patients was significantly lower. These changes in plasma concentrations of free amino acids are related to burn area, indicating that it is clinically meaningful.