论文部分内容阅读
为探讨肝癌特异性ＧＧＴ同工酶区带（ＨＳＢ）、谷胱苷肽－Ｓ－转换酶（ＧＳＴｓ）和肿瘤坏死因子（ＴＮＦ）３项血清学标志物浓度改变在肝癌诊断与鉴别中的临床价值，分别对肝癌、慢性肝病和肝外肿瘤进行定量检测分析。结果，肝癌组ＨＳＢ和ＧＳＴｓ浓度均明显高于慢性肝病和肝外肿瘤组（Ｐ＜０．０１）；ＴＮＦ浓度肝癌组明显高于慢性肝病组（Ｐ＜０．００１），但与肝外肿瘤组间无明显差异；肝癌组ＨＳＢ、ＧＳＴｓ和ＴＮＦ的阳性率分别为８８．６％、７８．１％和７４．３％，均显著高于另两组（Ｐ＜０．０１）。研究表明，ＨＳＢ定量检测优于ＧＳＴｓ和ＴＮＦ，多项指标联合分析有助于肝癌的诊断与鉴别。
To investigate the clinical significance of three serum markers of hepatoma-specific GGT isoenzymes (HSB), glutathione-S-converting enzyme (GSTs), and tumor necrosis factor (TNF) in the diagnosis and differential diagnosis of liver cancer The value of liver cancer, chronic liver disease and extrahepatic tumor were analyzed quantitatively. Results: The concentrations of HSB and GSTs in liver cancer group were significantly higher than those in chronic liver disease and extrahepatic tumor group (P<0.01). The TNF concentration in liver cancer group was significantly higher than that in chronic liver disease group (P<0.001), but with extrahepatic tumors. There was no significant difference between groups; the positive rates of HSB, GSTs, and TNF in liver cancer group were 88.6%, 78.1%, and 74.3%, respectively, which were significantly higher than those in the other two groups (P<0.01). Studies have shown that quantitative detection of HSB is superior to GSTs and TNF, and the combined analysis of multiple indicators is helpful for the diagnosis and identification of liver cancer.