多囊卵巢综合征(PCOS)以高雄激素血症和无排卵为特征,其它表现为肥胖,多毛,黄体生成激素(LH)分泌增加和高胰岛素血症。最近资料表明:高胰岛素血症在PCOS发病机理中起着重要作用,并指出口服降糖药可能为POCS的治疗提供一条新途径。下面介绍几种试用治疗PCOS患者高胰岛素血症的药物:二甲双胍、二氮嗪和troglitazone。 二甲双胍可抑制肝糖元的产生,增加外周组织对胰岛素的敏感性。近来有报道对肥胖PCOS患者应用二甲双胍可降低卵巢细胞 Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and anovulation, with other manifestations being obesity, hirsutism, increased secretion of luteinizing hormone (LH), and hyperinsulinemia. Recent data indicate that hyperinsulinemia plays an important role in the pathogenesis of PCOS and suggests that oral hypoglycemic agents may provide a new avenue for the treatment of POCS. Here are some of the trials to try hyperinsulinemia in patients with PCOS drugs: metformin, diazoxide and troglitazone. Metformin inhibits hepatic glycogen production and increases the sensitivity of peripheral tissues to insulin. Recently, it has been reported that the application of metformin to obese patients with PCOS can reduce ovarian cells