温度升高对胚胎发育能产生有害影响，然而亚致畸剂量的高热却能诱导胚胎对随后致畸程度的高热产生一定的耐受作用。本研究应用Ｗｉｓｔｅｒ种大鼠胚胎体外培养方法研究了这种热耐受作用，结果发现先给一次热休克处理（４２℃２０ｍｉｎ）可减少随后高热（４３℃１５ｍｉｎ）所致胚胎畸形的发生率。胚胎畸形率从５６．２５％减少到２３．５％，胚胎发育迟缓明显减轻。证实热休克具有保护胚胎对随后致畸程度高热的致畸作用的抵抗能力。 Increased temperature can have a detrimental effect on embryonic development, whereas sub-teratogenic doses of hyperthermia can induce embryos to tolerate hyperthermia that is followed by teratogenicity. In this study, Wister rat embryo culture in vitro study of this heat tolerance, and found that giving a heat shock treatment (42 ℃ 20min) can reduce the subsequent high fever (43 ℃ 15min) embryo malformations. Embryos deformity rate decreased from 56.25% to 23.5%, embryonic development was significantly reduced. Heat shock has been demonstrated to protect embryos against subsequent teratogenic teratogenic effects.