Loss of Dicer1 impairs hepatocyte survival and leads tochronic inflammation and progenitor cell acti

来源 :世界胃肠病学杂志：英文版（电子版） | 被引量 : 0次 | 上传用户：mmmzyh

【摘要】

：

AIM To investigate the continuous hepatic histopathologicalprocesses which occur in response to the lossof Dicer1.METHODS： We generated a hepatocyte-selectiveDic

【作者】

：

Lu Xu-Feng Zhou Yong-Jie Zha

【机构】

：

SichuanUniv,SichuanUniv,SichuanUniv

【出处】

：

世界胃肠病学杂志：英文版（电子版）

【发表日期】

：

2015年21期

【关键词】

：

Dicer1 microRNAs LIVER inflammation LIVER FIBROSIS HEPATOCELLULAR carcinoma Dice

【基金项目】

：

Supported by National Key Clinical Project,and National Sciences,and Technology Major Project of China,No.2012ZX10002-017

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AIM To investigate the continuous hepatic histopathologicalprocesses which occur in response to the lossof Dicer1.METHODS： We generated a hepatocyte-selectiveDicer1 knockout mouse and observed the gradualhepatic histopathological changes in the mutant liv

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