女患,58岁,于1989年7月10日入院。1986年起觉口干、咽干、异物感,进食需水协助,眼干,哭无泪,嗅觉不灵。逐渐出现四肢酸胀麻木,以双下肢为重。7个月来,行走时感觉双下肢及臀部酸痛,渐加重。体检:消瘦,面色苍白,毛发稀疏,皮肤、粘膜干燥。心、肺未见异常。肝、脾未触及。嗅觉丧失,舌前2/3味觉减退。四肢末端触觉减退,双下肢音叉振 Female patient, 58 years old, was admitted to hospital on July 10, 1989. Since 1986, dry mouth, throat, foreign body sensation, eating water to help dry eyes, tears, tears do not work. Gradually limbs sore numbness, with both lower extremities as the most important. In the past 7 months, I felt soreness in lower extremities and buttocks while walking, gradually increasing. Physical examination: weight loss, pale, thin hair, dry skin, mucous membranes. Heart, lung no abnormalities. Liver, spleen not touched. Loss of smell, 2/3 taste before the tongue diminished. Jaundice extremities touch, lower extremity tuning fork vibration