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目的自激素性青光眼首次报道以来已有50多年,人们对于激素性青光眼的危险因素、发病机制和防治都有了进一步的了解。原发性开角型青光眼患者及其亲属,高度近视眼患者等对激素治疗引起的眼压增高较敏感。糖皮质激素主要是通过糖皮质激素受体发挥作用,使小梁网的细胞外基质沉积,增加房水流出阻力而导致眼压升高。进一步了解激素性青光眼的危险因素和发病机制可以有助于我们更好的预防和治疗激素性青光眼。
OBJECTIVES More than 50 years have passed since the first report of steroid-induced glaucoma, and people have gained a better understanding of the risk factors, pathogenesis and prevention of steroid-induced glaucoma. Primary open-angle glaucoma patients and their relatives, patients with high myopia and other hormonal treatment caused by increased intraocular pressure is more sensitive. Glucocorticoids mainly through the glucocorticoid receptor play a role in the extracellular matrix trabecular meshwork deposition, increased resistance to aqueous humor caused by increased intraocular pressure. Further understanding of the risk factors and pathogenesis of steroid-induced glaucoma can help us to better prevent and treat steroid-induced glaucoma.