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目的探讨早期输注新鲜冰冻血浆在肝硬化食管胃底静脉曲张破裂出血(EVB)患者中的临床应用价值。方法回顾性分析2011—2016年于福建医科大学附属漳州市医院收治的肝硬化EVB住院患者286例,根据入院早期(发病时间<6 h)是否输注新鲜冰冻血浆分为对照组162例和新鲜冰冻血浆(FFP)组124例。患者入院后常规支持治疗,对照组患者未输注新鲜冰冻血浆,FFP组患者在入院时即申请输注新鲜冰冻血浆。比较两组患者住院期间及不同分级再出血率及病死率,并比较两组患者肝性脑病发生情况。结果两组患者住院期间再出血率、病死率比较,差异无统计学意义(P>0.05)。两组Child-pugh B、C分级患者再出血率、病死率比较,差异无统计学意义(P>0.05)。两组患者肝性脑病发生率比较,差异无统计学意义(P>0.05)。结论早期输注新鲜冰冻血浆并不能降低肝硬化EVB患者再出血率及病死率。
Objective To investigate the clinical value of early fresh frozen plasma transfusion in patients with cirrhosis esophageal variceal bleeding (EVB). Methods A retrospective analysis of 286 patients with EVB inpatients with cirrhosis admitted to Zhangzhou Hospital Affiliated to Fujian Medical University from 2011 to 2016 was conducted. According to whether fresh frozen plasma was infused into the control group of 162 patients with early or early onset of admission (onset time <6 h) 124 cases of frozen plasma (FFP) group. Patients were routinely supported after admission to treatment, patients in the control group were not infused with fresh frozen plasma, and patients in the FFP group were asked to apply for fresh frozen plasma at admission. The two groups of patients were compared during hospitalization and different grading rebleeding rate and mortality, and compared the incidence of hepatic encephalopathy in both groups. Results There was no significant difference in rebleeding rate and mortality between the two groups during hospitalization (P> 0.05). Two groups of Child-pugh B, C grading patients rebleeding rate, mortality rate, the difference was not statistically significant (P> 0.05). There was no significant difference in the incidence of hepatic encephalopathy between the two groups (P> 0.05). Conclusion Early infusion of fresh frozen plasma does not reduce the rate of rebleeding and mortality in cirrhotic patients with EVB.