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目的：视神经纤维分析仪（ＮＦＡ）测量的偏振延迟图以双峰曲线为特征，此双峰是早期青光眼的易损区。分析双峰曲线的形态及其在正常组的变异，与青光眼的分离情况，筛选出可靠、有效的诊断参数。方法：病人源于美国华盛顿大学眼科门诊，青光眼病人９２例１４３只眼，正常对照组８３例８３只眼。本研究有三类参数，（１）总值参数，即各象限总和值；（２）比值参数，即上或下象限与鼻象限的比值；（３）调制参数，由原始数据计算。首先求基线，即鼻、颞象限最低点的平均值。上或下象限调制峰值＝上或下象限最高点－基线；上或下象限调制总值＝上或下象限总值－基线下总值。结果：正常组及各期青光眼组的平均延迟曲线的特征是，基线部分在各组变化不明显，双峰依青光眼程度的加重而降低。早期青光眼组与正常组之间的延迟平均差比值：总值参数及比值参数为１３％～１６％，调制参数为２７％～３３％。结论：利用调制参数可明显地提高ＮＦＡ对早期青光眼诊断的敏感性及特异性。
PURPOSE: The polarization delay profile measured by the optic nerve fiber analyzer (NFA) is characterized by a bimodal curve that is a vulnerable area of early glaucoma. Analysis of bimodal curve morphology and its variation in the normal group, and the separation of glaucoma, screening out reliable and effective diagnostic parameters. Methods: The patients originated from the Eye Clinic of the University of Washington, USA, with 92 eyes of 143 eyes of glaucoma and 83 eyes of 83 eyes of normal control group. There are three types of parameters in this study: (1) the total value of the parameters, ie, the sum of the quadrants; (2) the ratio parameter, which is the ratio of the upper or lower quadrant to the nasal quadrant; and (3) the modulation parameters, which are calculated from the raw data. First seek the baseline, that is, the average nasal and temporal quadrant lowest point. Upper or lower quadrant Modulation peak = upper or lower quadrant highest point - baseline; upper or lower quadrant modulation total = upper or lower quadrant total - baseline total. Results: The average delay curve of the normal group and the glaucoma group was characterized by the fact that the baseline part did not change significantly in each group, and the double peak decreased as the degree of glaucoma increased. The average difference of retardation between early glaucoma group and normal group: the total value parameter and the ratio parameter are 13% ~ 16%, the modulation parameter is 27% ~ 33%. Conclusion: The use of modulation parameters can significantly improve the sensitivity and specificity of NFA in the diagnosis of early glaucoma.