论文部分内容阅读
经历了几十年的研究,但关于肿瘤的转移扩散仍存在很多未解的问题,其中最引人关注的是原发肿瘤转移产生的机制.传统观念认为转移是由原发肿瘤的单个循环肿瘤细胞播种的,且这种观念得到普遍认可.但随着研究技术及设备的进步,近期很多研究均表明肿瘤的转移需要肿瘤细胞团的集体行动,循环肿瘤细胞团作为肿瘤侵袭的一种形式,与肿瘤的远处播散密切相关,成为近期研究的热点.本文就循环肿瘤细胞团形成的大体过程、分子生物学特性及与肿瘤转移关系等方面作一综述.“,”There are still many unanswered questions about tumor metastasis through decades of study, one of the most concerned questions is the mechanism of primary tumor metastasis.Conventional concept suggests that metastasis was seeded by single circulating tumor cells from primary tumors, and this concept was generally adopted up to date.But with the improvement of study techniques and equipment, current research demonstrates that seeding requires the collective action of tumor cells traveling together in clusters.Curculating tumor cell clusters serve as a performance of tumor invasion, and strongly associate with tumor metastatic seed and become a study hotspot.This article mainly reviews the molecular biological features of curculating tumor cell clusters and the influence on the metastatic seed.