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目的 为研究血清总胆固醇与全癌、胃癌、肝癌以及肺癌死亡的关系 ,评价血清总胆固醇含量作为这几种癌的预报指标的价值。方法 研究人群是韩国医疗保险公司的投保人 ,且年龄在 4 0岁及 4 0岁以上 ,共有 6 98,796人。 1 992年至 1 993年首先对每一个观察对象进行身体健康检查并调查他们的生活习惯以及疾病既往史。随访开始于 1 994年 1月 1日结束于 2 0 0 0年 1 2月 31日。本研究的主要数据来自健康检查记录以及保险公司的死亡补贴记录。结果 随访期内有 1 1 754人死于癌症 ,其中 2 6 31人死于胃癌 ,2 4 56人死于肝癌 ,2 1 2 9人死于肺癌。血清总胆固醇水平与全癌、肝癌的死亡呈明显的负相关关系并且有统计学意义。血清胆固醇升高 ,全癌和肝癌的死亡率降低 ,不论男性还是女性均是同样的结果。排除随访期前 3年的死亡人数后 ,得到的仍然是这个结果。胆固醇与胃癌之间呈现弱的负相关关系。胆固醇与肺癌间无统计学联系。结论 胆固醇与全癌以及肝癌之间有负的相关关系 ,血清胆固醇含量过低预示死于全癌和肝癌的危险升高。
Objective To investigate the relationship between serum total cholesterol and total cancer, gastric cancer, liver cancer and lung cancer death and evaluate the value of serum total cholesterol as a predictor of these types of cancer. Methodology The study population was a contributor to a Korean medical insurance company with a mean age of 40 and over, with a total of 698,796 people. From 1992 to 1993, each observer was first examined for physical health and investigated their habits and past medical history. Follow-up began on January 1, 1994, ending on January 31, 2000. The main data for this study came from records of health checks and death-subsidy records from insurance companies. Results During the follow-up period, 11754 people died of cancer, of which 2631 died of gastric cancer, 2456 died of liver cancer and 2119 died of lung cancer. Serum total cholesterol levels and total cancer, liver cancer mortality was significantly negatively correlated and statistically significant. Elevated serum cholesterol, reduced overall cancer and liver cancer mortality, both men and women are the same result. After excluding the number of deaths in the three years prior to the follow-up period, the result was still obtained. Cholesterol and gastric cancer showed a weak negative correlation between. There was no statistical relationship between cholesterol and lung cancer. Conclusions Cholesterol has a negative correlation with total cancer and liver cancer. The low serum cholesterol is predicted to increase the risk of death from cancer and liver cancer.