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FK506是从Streptomyces tsukubaensis培养物中分离而得的一种大环内酯化合物,与淋巴细胞培养物混合后抑制淋巴细胞增殖的作用比环胞菌素大500倍,可逆转或防止动物许多器官移植的排异反应。临床研究表明FK506对肝脏移植受体的免疫抑制作用也比环胞菌素更有效,一般术后立即给药0.075mg/kg·d,其剂型为FK506与水合聚氧乙烯蓖麻油(HCO-60,非离子表面活性剂)制成10mg/ml溶液,静注时用0.9%氯化钠或5%葡萄糖稀释后,短时(2～4h)或持续用药。
FK506, a macrolide compound isolated from a Streptomyces tsukubaensis culture, inhibits lymphocyte proliferation when mixed with lymphocyte cultures more than 500 times larger than cyclosporine, reversing or preventing many organ transplants in animals Dissent response. Clinical studies have shown that the immunosuppressive effect of FK506 on liver transplant recipients is also more effective than cyclosporine. The dosage of FK506 is 0.075mg / kg · d immediately after the operation, and its dosage form is FK506 and hydrated polyoxyethylene castor oil (HCO-60 , Non-ionic surfactant) made of 10mg / ml solution, intravenous injection of 0.9% sodium chloride or 5% glucose diluted, short (2 ~ 4h) or continuous medication.