高剂量戊巴比妥已成功地用于头部损伤等降低颅内压。一种改进的给药方法是把药物稀释为大容积输液,用输液泵控制连续静脉输注。作者测定了临床上使用的两种不同大容积输液中不同浓度药物的稳定性,并评价了用终端滤器输注时的效果。每瓶大容积输液于混合前采样5ml,接着于混合后0、1、2、4、8和12小时各采样10ml,每次采样后立即测定澄明度、pH 和药物浓度。对血中的巴比妥酸盐,作者用改进的酶免疫法测定戊巴比妥浓度。作者对微粒沉淀用荧光光谱光散射分析法进行评价。0.9%氯化钠和5%葡萄糖注射液中的样品于荧光光谱测定仪中对照空白加以比较,为使微粒的光散射易于观察,将发射和激发波长调至450nm 处。结果表明在12小时内各瓶输液均保持澄明,用荧光光谱检测每 High-dose pentobarbital has been successfully used to reduce intracranial pressure such as head injury. An improved method of administration is to dilute the drug into a large volume of infusion, which is controlled by an infusion pump for continuous intravenous infusion. The authors measured the stability of different concentrations of drug in two different large volume transients used clinically and evaluated the effect of infusion with a final filter. A large volume of each infusion was sampled 5 ml before mixing, followed by 10 ml each at 0, 1, 2, 4, 8 and 12 hours after mixing, and the clarity, pH, and drug concentration were determined immediately after each sample. On barbiturates in blood, the authors used a modified enzyme immunoassay to determine pentobarbital concentrations. The authors evaluated the precipitation of particles using fluorescence spectroscopy. 0.9% sodium chloride and 5% glucose injection samples were compared in the fluorescence spectrophotometer comparison blank, in order to make the particles light scattering easy to observe, the emission and excitation wavelength adjusted to 450nm. The results showed that the transfusion of each bottle remained clear within 12 hours and each detected by fluorescence spectroscopy