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目的:通过对过山枫乙醇提取物对大鼠胶原诱导性关节炎模型的实验研究,探讨过山枫治疗类风湿性关节炎的药理作用机制和进行安全性评估,为下一步新药开发研究提供依据。方法:制作类风湿性关节炎大鼠模型,肾功能影响采用脲酶-BER ttelo法。结果:醇提小剂量组血清SOD含量显著高于模型组。给药30天,GSF对Ⅱ型胶原诱发关节炎模型大鼠肝脏功能无明显毒副作用,模型大鼠谷丙转氨酶、谷草转氨酶活性显著高于对照组。给药5周后,胸腺指数均高于模型对照组,水提组与模型组比较差异显著;实验组肝脏指数小于模型对照组。结论:过山枫乙醇提取物具有抗炎作用;过山枫乙醇提取物在治疗浓度时,对肝脏、肾脏和子宫等重要脏器没有明显的毒副作用。
OBJECTIVE: To investigate the pharmacological mechanism and safety assessment of Rhizoma Coccinellus on rheumatoid arthritis in rats by the experimental study of rat model of collagen-induced arthritis. in accordance with. METHODS: A rat model of rheumatoid arthritis was produced. The effect of renal function on urease-BER ttelo method was used. Results: The SOD content in the low-dose ethanol group was significantly higher than that in the model group. After 30 days of administration, GSF had no significant side effects on the liver function of rats with type II collagen-induced arthritis. The activity of glutamic-pyruvic transaminase and aspartate aminotransferase in model rats was significantly higher than that in the control group. After 5 weeks of administration, the thymus index was higher than that of the model control group. There was significant difference between the water withdrawal group and the model group. The liver index of the experimental group was smaller than that of the model control group. Conclusion: Ethanol extracts of Astragalus membranaceus have anti-inflammation effect; Ethanol extracts of Astragalus membranaceus have no obvious toxic side effects on important organs such as liver, kidney and uterus when treating concentration.