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目的分析慢性乙型肝炎(CHB)进展为肝硬化(LC)患者常见易患因素。方法 141例CHB-LC患者作为LC组,同期157例CHB非LC患者作为对照组,两组患者接受了“CHB进展为LC易患因素问卷”调查。结果 LC组的平均年龄、平均病程、肝脏病家族史、饮酒、氨酸转氨酶(ALT)、乙型肝炎病毒基因(HBV DNA)、血清铁、转铁蛋白饱和度及高乙型肝炎表面抗原(HBs Ag)临界指数例数均明显多于对照组,而甲胎蛋白(AFP)及低HBs Ag临界指数例数均明显少于对照组,差异有统计学意义(P<0.05)。结论年龄大、患病时间长、肝脏病家族史、饮酒、高HBs Ag临界指数及血清ALT、HBV DNA、血清铁、转铁蛋白饱和度增高均可成为CHB进展LC的易患因素。
Objective To analyze the common risk factors of chronic hepatitis B (CHB) progression to cirrhosis (LC). Methods One hundred and seventy-one CHB-LC patients were enrolled as LC group and 157 CHB non-LC patients as control group during the same period. Two groups of patients underwent questionnaire survey of CHB progression to LC susceptibility. Results The mean age, mean duration of disease, family history of liver disease, alcohol consumption, ALT, HBV DNA, serum iron, transferrin saturation and high hepatitis B surface antigen (LC) HBs Ag) were significantly higher than those in the control group, while the critical number of AFP and low HBs Ag were significantly less than that of the control group (P <0.05). CONCLUSION: The risk factors of CHB progression LC may be large age, prolonged illness, family history of liver disease, alcohol consumption, high criticality index of HBsAg, serum ALT, HBV DNA, serum iron and transferrin saturation.