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无脊椎动物的血细胞中存在着各种生物活性物质,其中,鲎中含有的Tachyplesin很受重视,已证明它对革兰氏阳性、阴性菌、白色念珠菌等均有抗菌作用。从日本产鲎血细胞中分离出的Tachyplesin分二种,均为C端含有α-酰胺的17个氨基酸构成的肽链,从美洲产鲎血细胞中分离出的Polyphemsin有二种,为N端带有一个精氨酸的18个氨基酸构成的肽链1.强力的抗艾滋病毒活性作者证实了天然Tachyplesin和Polyphemsin在试管中有抗艾滋病毒活性。然而,其毒性很强,抗艾滋病毒活性浓度的2～10倍即对感染宿主细胞产生毒性。于是作者对此
There are a variety of bioactive substances in the blood cells of invertebrates. Among them, Tachyplesin contained in tamarins has received great attention. It has been shown to have antibacterial activity against Gram-positive bacteria, Negative bacteria and Candida albicans. Tachyplesin, which is isolated from Japanese hemagglutinin cells, is divided into two 17-amino acid peptide chains containing the α-amide at the C-terminus. Polyphemsin isolated from the blood of the American caprine is divided into two types, An 18 amino acid peptide chain of arginine 1. Robust anti-HIV activity The authors confirmed that natural Tachyplesin and Polyphemsin have anti-HIV activity in vitro. However, its toxicity is very strong, 2 to 10 times the concentration of anti-HIV activity that is toxic to infected host cells. So the author of this