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目的:研究间变性大细胞淋巴瘤的细胞学病理特征和免疫表型。方法:回顾性分析11例间变性大细胞淋巴瘤患者的临床表现和病理形态学资料,以及免疫组织化学CD30、间变性淋巴瘤激酶、EMA等检测结果。结果:间变性淋巴瘤激酶阳性患者9例(81.82%),阴性2例(18.18%),CD30表达11例(100%),EMA表达6例(54.55%),CD43表达8例(72.73%),CD20表达1例(9.09%),CD45RO表达1例(9.09%),CD3、CD56、PCK、CD117都没有表达。结论:间变性大细胞淋巴瘤患者的临床表现多样化,容易误诊成霍奇金淋巴瘤、恶性黑色素瘤等,如果经过临床、细胞病理学和免疫标记特征等综合进行判断,就能够做出正确的诊断。
Objective: To study the cytological pathology and immunophenotype of anaplastic large cell lymphoma. Methods: The clinical manifestations and pathomorphological data of 11 patients with anaplastic large cell lymphoma were retrospectively analyzed. The detection results of immunohistochemical CD30, anaplastic lymphoma kinase and EMA were retrospectively analyzed. Results: There were 9 cases (81.82%) with anaplastic lymphoma kinase in 2 cases (18.18%), CD30 expression in 11 cases (100%), EMA expression in 6 cases (54.55%) and CD43 expression in 8 cases (72.73% 1 case (9.09%) showed CD20 expression and 1 case (9.09%) showed CD45RO expression. CD3, CD56, PCK and CD117 were not expressed. Conclusions: The clinical manifestations of patients with anaplastic large cell lymphoma are diversified and easily misdiagnosed as Hodgkin’s lymphoma and malignant melanoma. If the clinical, cytopathological and immunological characteristics of the patients are comprehensively evaluated, they can be correctly identified Diagnosis.