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目的通过温肺止流丹对肺气虚型变态反应性鼻炎(AR)大鼠模型血清IL-4和鼻粘膜IL-4mRNA表达影响的研究,为临床运用该药治疗AR提供实验依据。方法采用病证结合的方法造模,用RT-PCR法检测鼻黏膜IL-4 mRNA的表达。结果温肺止流丹能够降低实验性AR大鼠血清IL-4和鼻黏膜IL-4 mRNA的表达。结论温肺止流丹可能通过调节IL-4 mRNA的表达,对实验性AR大鼠发挥治疗作用。
Objective To study the effect of Wenfeizhi Zhidan on IL-4 and IL-4mRNA in nasal mucosa of rats with lung Qi Deficiency Allergic Rhinitis (AR), and to provide experimental evidence for the clinical use of this drug in the treatment of AR. Methods The method of combination of disease and syndrome was used to establish the model. The expression of IL-4 mRNA in nasal mucosa was detected by RT-PCR. Results Wenfeizhisidan could decrease the expression of IL-4 and IL-4 mRNA in the nasal mucosa of experimental AR rats. Conclusions Wenfei Zhidan may exert a therapeutic effect on experimental AR rats by regulating the expression of IL-4 mRNA.