老年人药源性疾病主要有:(1)药源性血质不调,如再生障碍性贫血、粒细胞减少症、溶血性贫血、巨幼红细胞性贫血和血小板减少症。(2)药源性肝毒性反应,如“细胞毒性”损害、“胆汁郁积”损害。(3)药源性肾毒性反应,如肾小球肾炎、间质性肾炎、肾小管坏死。(4)药源性皮肤病,如痤疮样皮疹、剥脱性皮炎、多形性红斑、固定皮疹、红斑狼疮样反应、光敏感性反应、中毒性表皮坏死溶解。 对住院病人的研究表明,年老者发生药源性疾病的危险增加,并 Drug-induced diseases in the elderly are: (1) drug-induced irregular blood quality, such as aplastic anemia, neutropenia, hemolytic anemia, megaloblastic anemia and thrombocytopenia. (2) Drug-induced liver toxicity, such as “cytotoxic” damage, “cholestasis” damage. (3) Drug-induced nephrotoxicity, such as glomerulonephritis, interstitial nephritis, tubular necrosis. (4) drug-induced skin diseases such as acne-like rash, exfoliative dermatitis, erythema multiforme, fixed rash, lupus-like reaction, light-sensitive reaction, toxic epidermal necrolysis. Studies of hospitalized patients have shown an increased risk of drug-induced illness in older adults