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目的:探讨妊娠期肝内胆汁淤积症(ICP)孕妇的血清甘胆酸(CG)、总胆汁酸(TBA)水平与围生儿预后的关系。方法:选择ICP患者90例为研究组,正常孕妇90例为对照组,分别测定孕妇血清甘胆酸(CG)和血清总胆汁酸(TBA)水平。结果:ICP孕妇血清CG、TBA水平较对照组明显增高,且胎儿窘迫、新生儿窒息、新生儿早产及新生儿死亡的发生率亦增高。结论:测定孕妇血清CG、TBA水平可作为预测ICP及提高ICP诊断、预测围生儿预后的方法。
Objective: To investigate the relationship between the levels of serum glycocholic acid (CG) and total bile acid (TBA) in pregnant women with intrahepatic cholestasis of pregnancy (ICP) and the prognosis of perinatal infants. Methods: Ninety patients with ICP were selected as research group and 90 normal pregnant women as control group. The level of serum CG and TBA in pregnant women were determined. Results: The levels of serum CG and TBA in ICP pregnant women were significantly higher than those in control group, and the incidence of fetal distress, neonatal asphyxia, neonatal premature birth and neonatal death were also increased. Conclusion: The determination of serum CG and TBA levels in pregnant women can be used as a method to predict ICP, improve ICP diagnosis and predict perinatal prognosis.