H因子是补体激活替代途径的调节蛋白,通过结合到C3b上来调节补体的级联反应,并作为Ⅰ因子的辅因子将C3b转变为iC3b.该因子由人外周血单核细胞合成,并发现于人的血小板和淋巴细胞.它可特异地结合到细胞表面膜受体上,并且启动某些细胞功能。人体B淋巴细胞和巨噬细胞携带有H因子的表面受体。为了解该因子对这些细胞的功能调节作用,作者对体外培养的外周血单核细胞和B淋巴细 Factor H is a regulatory protein for complement-activated alternative pathways that regulate the complement cascade by binding to C3b and convert C3b to iC3b as a cofactor for factor I. The factor is synthesized by human peripheral blood mononuclear cells and found in Human platelets and lymphocytes, which bind specifically to cell surface membrane receptors and initiate certain cellular functions. Human B lymphocytes and macrophages carry a factor H surface receptor. In order to understand the function of these factors on the regulation of these cells, the authors of in vitro cultured peripheral blood mononuclear cells and B lymphocytes