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为了减少生物材料为中心的感染 (BCI) ,采用N2 低温等离子体沉积 (LTP)、二次等离子体、紫外 (UV)辐照与化学方法相结合的实验技术 ,对人工心瓣用Dacron材料进行了改性。在其材料表面引入聚乙二醇 (PEG) ,利用PEG的“化学放大”作用再引入肝素 (Hep) ,经表皮葡萄球菌 (SE)体外动态粘附实验比较 ,紫外辐照与化学方法相结合的改性抗细菌粘附效果最好 ,细菌粘附减少 90 % ,二次等离子体改性次之 ,细菌粘附减少 80 % ,N2 低温等离子体沉积后抗细菌粘附效果有一定的提高。
To reduce biomaterial-centered infection (BCI), Dacron material was applied to the heart valve using N2 cryogenic plasma deposition (LTP), secondary plasma, and UV irradiation combined with chemical methods Modified. The introduction of polyethylene glycol (PEG) on the surface of the material, the use of PEG “chemical amplification” and then the introduction of heparin (Hep), Staphylococcus epidermidis (SE) in vitro dynamic adhesion experiments, UV irradiation combined with chemical methods The results showed that bacterial adhesion was reduced by 90%, followed by secondary plasma modification followed by reduction of bacterial adhesion by 80%. The antibacterial adhesion effect of N2 plasma was improved after the low temperature plasma deposition.