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胶质瘤是严重威胁人类健康的恶性肿瘤,其生长迅速,侵润性强,复发率高,预后差。胶质瘤干细胞的发现为胶质瘤的研究提供了新的切入点。Nestin属于第Ⅵ类中间丝蛋白,自发现以来一直被认为是神经前体细胞的标志物,近年来在胶质瘤干细胞的研究中有一定的应用。本文综述了Nestin在胶质瘤干细胞鉴定及其表达在胶质瘤进展和预后中的作用,为胶质瘤研究提供理论资料。
Glioma is a serious threat to human health of malignant tumors, its rapid growth, strong invasive, high recurrence rate, poor prognosis. The discovery of glioma stem cells provides a new entry point for the study of glioma. Nestin, a type VI intermediate silk protein, has been considered as a marker of neural progenitor cells since its discovery. In recent years, it has some applications in the research of glioma stem cells. This review summarizes the role of Nestin in the identification of glioma stem cells and its role in the progression and prognosis of gliomas, providing theoretical information for glioma research.