两项新的研究报道,在自发性慢性胰腺炎与囊性纤维变性跨膜调节器(CFTR)基因突变之间存在密切的联系。美国达勒姆市杜克医学中心的JonathanCohn及其小组对27名病人的CFTR基因进行了研究,这些病人表现有不明原因的胰腺炎,但是没有典型的囊性纤维变性肺疾病的迹象。8名病人有已知能引起传统的囊性纤维变性的突变;5名病人有使病人易感无肺病性阻塞性精子缺乏症的等位基因。发生突变的次数是普通人群的11倍。在3名病人 Two new studies have reported a close relationship between spontaneous chronic pancreatitis and mutations in the cystic fibrosis transmembrane regulator (CFTR) gene. Jonathan Cohn and his team at Duke Medical Center in Durham, United States, studied CFTR genes in 27 patients with unexplained pancreatitis but without signs of a classic cystic fibrosis lung disease. Eight patients had mutations known to cause traditional cystic fibrosis; five patients had alleles that made the patient susceptible to obstructive sperm deficiency without pulmonary disease. The number of mutations is 11 times that of the general population. In 3 patients