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考察了缩泉胶囊与山药、益智仁、乌药3味组方药材指纹图谱的相关性,为缩泉胶囊指纹图谱的检测标准提供参考。采用高效液相色谱法,使用Agilent Zorbax SB-C_(18)色谱柱,以乙腈∶0.1%磷酸为流动相,梯度洗脱,检测波长280 nm(0~21 min)、260 nm(21~33 min)和230 nm(33~50 min)。结果 10批样品共标定14个共有峰,样品指纹图谱相似度均大于0.90,缩泉胶囊与组方药材间指纹图谱的相关性良好。
Studied the shrinking capsule and yam, Yizhu Ren, Wu medicine group of three herbs prescription fingerprint correlation, for Quan Capsule fingerprint detection standards provide a reference. High performance liquid chromatography (HPLC) was performed on an Agilent Zorbax SB-C 18 column using acetonitrile: 0.1% phosphoric acid as the mobile phase with gradient elution at 280 nm (0-21 min) and 260 nm min) and 230 nm (33 ~ 50 min). Results Ten batches of samples were screened for 14 common peaks. The similarity of the fingerprints of the samples were all greater than 0.90. The correlation between Shuiquan capsule and the fingerprint of the prescription herbs was good.