近年来关于神经内分泌活动对月经周期的控制,特别是神经信号如何转化成内分泌语言方面取得了显著进展。根据对恒河猴的研究,有假设认为,在内侧基底下丘脑内可能存在一个“转换器”(Transducer),它将进入该区域的神经信号与内分泌信号进行整合并将其转化成具有一定频率与振幅的振荡信号。后者引起GnRH 以脉冲的方式释入垂体门脉循环。而GnRH 又决定了LH 与FSH 的分泌方式。传到神经转换器或“GnRH 振荡器”(GnRH oscillator)的神经信号的精确特征尚未确定。但已表明卵巢内分泌环境以一种特殊的方式调制该振荡器。如孕酮可明显地改变GnRH 振荡器的频率而导致LH 脉冲频率的显 In recent years, remarkable progress has been made in controlling the menstrual cycle of neuroendocrine activity, in particular how neuronal signals are converted into endocrine language. Based on studies of rhesus monkeys, it is hypothesized that there may be a “Transducer” within the medial basal hypothalamus that integrates the neuronal and endocrine signals into this region and converts it into a signal with a certain frequency Oscillation signal with amplitude. The latter causes GnRH to release into the pituitary portal circulation in a pulsatile manner. GnRH determines the secretion of LH and FSH. The exact nature of the neural signal that is passed to the neural switch or the “GnRH oscillator” has not been determined. However, it has been shown that the ovarian endocrine environment modulates the oscillator in a special way. Such as progesterone can significantly change the frequency of the GnRH oscillator and lead to significant LH pulse frequency