钩端螺旋体(以下简称钩体)病可累及整个神经系统(脑、脊髓以至周围神经)。Costa和Troisier子1916年首先报道人的钩体脑膜炎。我国于1939年报道2例由犬型钩体感染引起有脑膜炎症状的患者。有关钩体病的神经系统损害亦早已有专著介绍,但主要是急性期的表现。钩体病后发的神经系统表现过去只限于个别案 Leptospira (hereinafter referred to as leptospirosis) disease can affect the entire nervous system (brain, spinal cord and peripheral nerves). Costa and Troisier son first reported in 1916 human leptomeningeitis. In 1939, China reported 2 cases of meningitis caused by infection of canine leptospirosis. The nervous system damage related to leptospirosis has long monographs, but mainly the performance of the acute phase. Nervous system after the onset of leptospirosis in the past only limited to individual cases