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目的：探讨右佐匹克隆对失眠患者日间功能的影响。方法将抑郁症伴失眠患者125例随机分为右佐匹克隆组64例和艾司唑仑组61例，分别给予右佐匹克隆和艾司唑仑观察4周。4周后采用日间功能障碍量表评定疗效。结果治疗4周，日间功能障碍评定量表中除困倦项两组差异无统计学意义外(t=0.78，P>0.05)，其他项如白天乏力、打盹、精神差、反应迟钝、共济失调、判断力下降、意识模糊、精神紊乱上差异均有统计学意义(t分别=2.74，3.34，6.57，10.01，3.06，9.46，11.12，4.45；P均＜0.01)。结论右佐匹克隆对失眠患者日间功能的影响显著低于艾司唑仑。“,”Objective: To investigate the eszopiclone impact on daytime function in patients with insomnia.Method:125 cases of patients with depression with insomnia were randomly divided into 64 cases of eszopiclone group of 61 cases with the estazolam group were given the eszopiclone and estazolam to improve insomnia,observed four weeks. Assessment of adverse reactions in the treatment of four weeks of treatment were used to evaluate the efficacy of daytime dysfunction scale. Results: 4 weeks of treatment, daytime dysfunction rating scale except for drowsiness items between the two groups has no significant differences (t=0.78,P>0.05), the remaining items the differences were statistically significant in daytime fatigue, nap, mental difference, slow reation, ataxia, poor judgment, fuzzy thinking, mental disorder (t=2.74,3.34, 6.57,10.01,3.06,9.46,11.12,4.45;all P<0.01). Conclusion: Eszopiclone impact on daytime function in patients with depression accompanied by insomnia was significantly lower than estazolam.