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本文采用放免法和GFU-202原子吸收分光光度计测定57例脑梗塞病人的SOD和血清铜锌含量。17例发病7天内、40例8~20天内测定SOD,与正常对照组(25例)比较有显著和极显著差异。57例血清铜,锌含量与正常对照组比较有显著差异;铜,锌含量与SOD活性下降呈十分显著正相关性(P<1%)。提示脑梗塞病人随着病程的增长SOD活性下降,梗塞后血清铜、锌含量下降,显示微量元素与SOD一样对脑梗塞后的脑细胞损害有着密切关系。
In this paper, radioimmunoassay and GFU-202 atomic absorption spectrophotometer determination of 57 patients with cerebral infarction in patients with SOD and serum copper and zinc content. Within 17 days of onset of disease, SOD was detected in 40 cases within 8-20 days after onset, and there were significant and extremely significant differences compared with the normal control group (25 cases). 57 cases of serum copper, zinc content compared with the normal control group were significantly different; copper, zinc content and SOD activity was significantly decreased (P <1%). It suggested that the activity of SOD decreased with the increase of course of disease. The level of serum copper and zinc decreased after infarction. It showed that trace elements and SOD were closely related to the damage of brain cells after cerebral infarction.