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近十年来立体定向合成在天然产物和药物合成中的应用日益广泛,这和有机化学领域中许多新反应、新试剂、新方法研究所取得的成就是分不开的。立体定向合成是通过立体化学控制反应的进程和结局。它涉及反应的区域选择性(regioselectivity)或区域控制(regiocontrol),以及非对映立体选择性与对映选择性(Diastereoselectivity和enantio-selectivity)的问题,前者涉及试剂到达反应部位方向的判别,后者涉及空间排列对反应
The application of stereospecific synthesis in natural products and drug synthesis has been increasingly widespread in recent ten years, which is inseparable from many new reactions, new reagents and new methods in organic chemistry. Stereotactic synthesis controls the progress and outcome of the reaction through stereochemistry. It involves regioselectivity or regiocontrol of the reaction as well as diastereoselectivity and enantio-selectivity problems. The former involves the determination of the direction the reagent reaches the reaction site. The latter Involved in the spatial arrangement of the reaction