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头孢拉定为美国施贵宝制药公司专利的半合成头孢类抗生素,对革兰氏阳性及阴性菌均有杀菌作用;不受青霉素酶的影响,对大多数产青霉素酶的金黄色葡萄球菌和大肠杆菌亦有显著的抗菌活性。本品的剂型有胶囊、干混悬剂及无菌粉针。 临床药理学 头孢拉定在酸性条件下稳定,空腹服用吸收迅速。正常成人口服250、500、1000mg,1h后平均血清浓度峰值分别为9、16.5、24.2μg/ml;血清蛋白结合率低,仅6％。食物可延缓本品的吸收,但不影响吸收的总量,在6h内90％以上的主药以原形从尿中排出,在各组织中的浓度均较主要致病菌的最低抑菌浓度高出很多。
Cephradine is a semi-synthetic cephalosporin antibiotic patented by the United States Squibb Pharmaceutical Company, and has bactericidal effect on Gram-positive and -negative bacteria. In addition to penicillinase, cefradine also inhibits most penicillinase-producing Staphylococcus aureus and Escherichia coli Significant antibacterial activity. The product formulations of capsules, dry suspension and sterile powder. Clinical Pharmacology Cephradine is stable under acidic conditions and takes fast on an empty stomach. Normal adult oral 250,500,1000 mg, after 1h the average serum concentration peak were 9,16.5,24.2μg / ml; serum protein binding rate was low, only 6%. Food can delay the absorption of this product, but does not affect the total amount of absorption, within 6h 90% of the main drug from the urinary excretion of the prototype, the concentration in each tissue than the main pathogenic bacteria minimum inhibitory concentration A lot of.