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花生四烯酸(AA)在人体内含量丰富,其代谢产物具有重要病理生理作用,已经证实花生四烯酸经细胞色素P450(CYP450)羟化酶ω-羟化后生成的20-羟二十烷四烯酸(20-HETE)在原发性高血压发生机制中发挥了重要的作用。目前认为CYP4A11和4F2是人类代谢AA生成20-HETE的主要合成羟化酶,而一些研究证实CYP4A11和4F2基因编码区或启动子区的多态性会影响CYP450酶的功能,进而与心血管疾病尤其是原发性高血压的易感性相关。本研究着重对20-HETE参与血压调节的机制以及这两种基因多态性与原发性高血压关系的研究进展进行阐述。
Arachidonic acid (AA) in the human body is rich in content, the metabolites have an important pathophysiological effects, has been confirmed arachidonic acid by cytochrome P450 (CYP450) hydroxylase ω-hydroxylation of 20-hydroxy twenty Alktraconic acid (20-HETE) plays an important role in the pathogenesis of essential hypertension. It is currently thought that CYP4A11 and 4F2 are the major synthetic hydroxylases that human metabolites of AA produce 20-HETE. However, some studies have confirmed that CYP4A11 and 4F2 polymorphisms in the coding region or promoter region may affect the function of CYP450 enzymes and thus may be associated with cardiovascular diseases Especially the predisposition of essential hypertension. The present study focuses on the mechanism of 20-HETE involved in blood pressure regulation and the relationship between these two genetic polymorphisms and essential hypertension.