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目的:探讨抑癌基因PTEN在宫颈癌及癌前病变组织中的表达及意义。方法:选取110例石蜡包埋宫颈病变组织,其中慢性宫颈炎组织30例,宫颈上皮内瘤变(cervical intraepithelial neoplasia CIN)Ⅰ、Ⅱ、Ⅲ级组织分别为25、15、10例,浸润性宫颈鳞癌组织30例(Ⅰ、Ⅱ、Ⅲ～Ⅳ期各10例)。应用免疫组化方法检测PTEN蛋白在上述组织中的表达。结果:PTEN在慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ、浸润性宫颈鳞癌组织中,阳性表达率分别为100.00%、92.00%、73.33%、40.00%、36.67%,表达率逐渐下降,差别有统计学意义(P<0.05)。PTEN表达与宫颈鳞癌病理分期有关(P<0.05)。结论:PTEN与宫颈癌的发生、发展有关。
Objective: To investigate the expression and significance of tumor suppressor gene PTEN in cervical cancer and precancerous lesions. Methods: Totally 110 cases of paraffin-embedded cervical lesions were selected. Among them, 30 cases of chronic cervicitis and 1 cases of cervical intraepithelial neoplasia CIN were 25, 15 and 10 cases respectively. Invasive cervical Squamous cell carcinoma in 30 cases (Ⅰ, Ⅱ, Ⅲ ~ Ⅳ in 10 cases). Immunohistochemistry was used to detect the expression of PTEN protein in the above tissues. Results: The positive rates of PTEN in chronic cervicitis, CINⅠ, CINⅡ, CINⅢ and invasive cervical squamous cell carcinoma were 100.00%, 92.00%, 73.33%, 40.00% and 36.67%, respectively. The difference was statistically significant Significance (P <0.05). The expression of PTEN was related to the pathological stage of cervical squamous cell carcinoma (P <0.05). Conclusion: PTEN is related to the occurrence and development of cervical cancer.