目的探讨孕妇血清维生素D水平与胎膜早破的相关性。方法将80例胎膜早破孕妇作为观察组,80例非胎膜早破的孕妇作为对照组,并分别按血清25羟维生素D(25OHD)水平分为观察组A(维生素D缺乏与不足组)、观察组B(维生素D正常组)、对照组A(维生素D缺乏与不足组)、对照组B(维生素D正常组),比较各组25OHD水平及生殖道感染指标,并对结果进行统计学分析。结果观察组A的生殖道感染率明显高于观察组B,差异有统计学意义(P<0.05);对照组A的生殖道感染率明显高于对照组B,差异有统计学意义(P<0.05);观察组A的生殖道感染率与对照组A比较,两组差异无统计学意义(P>0.05);观察组的生殖道感染率、维生素D缺乏与不足率均明显高于对照组,差异有统计学意义(P<0.05)。结论孕妇血清维生素D缺乏与不足容易出现生殖道感染,从而增加胎膜早破的发生率,有必要在孕期进行25OHD测定,对维生素D缺乏与不足者通过补充维生素D,减少胎膜早破的发生,从而达到减少母婴并发症,提高生活质量的目标。 Objective To investigate the correlation between serum vitamin D levels and premature rupture of membranes in pregnant women. Methods Eighty pregnant women with premature rupture of membranes were selected as the observation group and 80 pregnant women without premature rupture of membranes as the control group. The levels of serum 25-hydroxyvitamin D (25OHD) were divided into observation group A (vitamin D deficiency group and deficiency group ), Observation group B (vitamin D normal group), control group A (vitamin D deficiency and deficiency group), control group B (vitamin D normal group), 25OHD level and genital tract infection index of each group were compared, and the results were statistically Analysis. Results The infection rate of reproductive tract in observation group A was significantly higher than that in observation group B (P <0.05), and the infection rate of reproductive tract in control group A was significantly higher than that in control group B (P < 0.05). The prevalence of genital tract infection in observation group A was not significantly different from that in control group A (P> 0.05). The rates of genital tract infection, vitamin D deficiency and deficiency in observation group were significantly higher than those in control group , The difference was statistically significant (P <0.05). Conclusion Pregnant women with serum vitamin D deficiency and deficiency prone to reproductive tract infections, thereby increasing the incidence of premature rupture of membranes, it is necessary to carry out 25OHD determination during pregnancy, vitamin D deficiency and deficiency by vitamin D, reduce premature rupture of membranes Occur, so as to achieve the goal of reducing maternal and child complications and improving the quality of life.