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目的观察抑毒调平液对慢性乙肝患者Th1/Th2细胞因子的影响。方法60例慢性乙型肝炎(中度)患者按随机双盲原则分为治疗组、对照组(每组30例)。两组分别口服抑毒调平液或安慰剂。收集治疗前、治疗后停药时及停药3月末空腹血清标本,用酶联免疫吸附法检测细胞因子白细胞介素-2、白细胞介素-4、白细胞介素-12、干扰素-γ。另选30例年龄、性别与治疗组、对照组无差异的正常人作正常组。结果治疗前治疗组、对照组患者血清IL-2、IFN-γ、IL-12的水平及IFN-γ/IL-4明显低于正常人(P<0.05),IL-4的含量明显高于正常人(P<0.05),治疗组与对照组患者间上述各项指标比较均无显著差异(P>0.05);治疗后停药时、停药3月末治疗组IL-2、IL-12、IFN-γ、IFN-γ/IL-4的值持续增加(P<0.05),IL-4持续下降(P<0.05),而对照组无明显变化(P>0.05)。结论抑毒调平液上调血清中IL-2、IL-12、IFN-r的含量及IFN-γ/IL-4的比值,下调IL-4的含量,促使Th1/Th2分泌的细胞因子比值恢复平衡,至少维持治疗结束后3个月。
Objective To observe the effects of Tanshunling Tablet on Th1 / Th2 cytokines in chronic hepatitis B patients. Methods Sixty patients with chronic hepatitis B (moderate) were divided into treatment group and control group (30 cases in each group) according to the principle of random double-blind. Two groups were oral anti-venom liquid or placebo. Fasting serum samples were collected before treatment, withdrawal after treatment and withdrawal at the end of March, and cytokines interleukin-2, interleukin-4, interleukin-12 and interferon-γ were detected by enzyme-linked immunosorbent assay. Another 30 cases of age, sex and treatment group, normal control group no difference normal group. Results The levels of IL-2, IFN-γ, IL-12 and IFN-γ / IL-4 in the treatment group and the control group before treatment were significantly lower than those in the normal control group (P <0.05) (P <0.05). There was no significant difference between the treatment group and the control group (P> 0.05). After stopping the treatment, the levels of IL-2, IL-12, The levels of IFN-γ and IFN-γ / IL-4 increased continuously (P <0.05), but IL-4 decreased continuously (P <0.05), but there was no significant change in control group (P> 0.05). Conclusion YFDH can up-regulate the levels of IL-2, IL-12 and IFN-γ and the ratio of IFN-γ / IL-4 in serum, decrease the level of IL-4 and promote the secretion of Th1 / Th2 cytokines Balance, at least 3 months after the end of treatment.