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目的分析儿童良性癫痫发作间期癫痫样放电对睡眠结构的影响。方法选取2005年6月—2010年6月我院收治的伴中央颞区棘波的良性癫痫患儿42例作为研究组,另选取同期我院体检健康儿童22例作为对照组。监测两组受试者多导睡眠生理脑电描记技术(PSG)、脑电图(EEG)、眼动图、肌电图等,观察其总睡眠时间(TSA)、睡眠潜伏期时间(SL)、非快速眼动睡眠相(NREM)各期快速眼动睡眠相(REM)睡眠时间和潜伏期、各期的棘波分布。结果研究组中癫痫样放电发生于觉醒期8例,占19.0%;睡眠期25例,占59.5%,其中发生在NREMⅠ、Ⅱ期19例,占76.0%;NREMⅢ、Ⅳ期4例,占16.0%,REM期2例,占8.0%。研究组SL、NREMⅠ、Ⅱ期长于对照组,NREMⅢ、Ⅳ期短于对照组(P<0.01);两组总睡眠时间、REM期比较,差异无统计学意义(P>0.05)。结论癫痫样放电与睡眠有一定的关系,其可影响患儿睡眠结构,降低其睡眠质量。
Objective To analyze the effect of epileptiform discharge on sleep structure in children with benign epileptic seizures. Methods Forty-two benign epilepsy patients with centrotemporal spikes in our hospital from June 2005 to June 2010 were selected as the study group, and 22 healthy children in our hospital were selected as the control group. The polysomnography (PSG), electroencephalogram (EEG), eye movement and electromyography of the two groups were monitored. The total sleep time (TSA), sleep latency (SL) Non-REM sleep phase (NREM) fast eye movement sleep phase (REM) sleep time and latency, the spike wave distribution. Results In the study group, epileptiform discharge occurred in wakefulness in 8 cases, accounting for 19.0%; in sleep stage, 25 cases (59.5%) occurred in 19 cases of NREMⅠand Ⅱ, accounting for 76.0%; in NREMⅢ and Ⅳ, 4 cases (16.0%) %, 2 cases of REM, accounting for 8.0%. There was no significant difference between the two groups in the total sleep time and the REM period (P> 0.05). The levels of SL, NREMⅠ and Ⅱ in the study group were longer than those in the control group, while those in the NREMⅢ and Ⅳperiods were shorter than those in the control group (P <0.01). Conclusion Epileptiform discharges have a certain relationship with sleep, which can affect children’s sleep structure and reduce their sleep quality.