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目的探讨胸腔积液中肿瘤特异性生长因子(TSGF)检测对肺癌的诊断价值。方法采用生化比色法与放射免疫分析法测定48例肺癌患者胸腔积液、血清及35例非肺癌患者胸腔积液中TSGF、CEA、CA125和CYFRA21-1的含量。结果肺癌组胸腔积液中4项标志物平均水平明显高于其他两组的平均水平(均P<0.01);肺癌组胸腔积液中4项标志物水平均高于血清中4项标志物水平(P<0.01);TSGF诊断肺癌敏感性(85.42%)分别高于CEA、CA125和CY-FRA21-1(41.67%、58.33%、58.33%),差异均有统计学意义(P<0.01～P<0.005);TSGF诊断肺癌敏感性(85.42%)与CEA、CA125和CYFRA21-1三项联合检测诊断肺癌的敏感性(79.16%)差异无统计学意义(P>0.05)。结论胸腔积液中TSGF检测对肺癌的诊断具有重要价值。
Objective To investigate the diagnostic value of tumor specific growth factor (TSGF) in pleural effusion for lung cancer. Methods The contents of TSGF, CEA, CA125 and CYFRA21-1 in pleural effusion of 48 patients with lung cancer, serum and 35 patients with non-lung cancer were determined by biochemical colorimetry and radioimmunoassay. Results The average levels of four markers in pleural effusion in lung cancer group were significantly higher than those in other two groups (all P <0.01). The levels of four markers in pleural effusion of lung cancer group were all higher than those in serum (P <0.01). The sensitivity of TSGF in diagnosing lung cancer was 85.42% higher than that of CEA, CA125 and CY-FRA21-1 respectively (41.67%, 58.33%, 58.33%), the difference was statistically significant <0.005). The sensitivity of TSGF in diagnosing lung cancer (85.42%) and CEA, CA125 and CYFRA21-1 were no significant difference (79.16%) (P> 0.05). Conclusions The TSGF detection in pleural effusion is of great value in the diagnosis of lung cancer.