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AIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy(DR) grade in type 2 diabetic patients.·METHODS: Aqueous humor and plasma samples from26 patients with DR(in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 p.m. Melatonin concentrations were determined using an enzyme-linked immunosorbent assay(ELISA).·RESULTS: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy(PDR) [18.57 ±2.67 pg/m L(range 15.20-23.06)vs 13.63±2.71 pg/m L(range 10.20-20.20), P =0.0001], but not in those with nonproliferative retinopathy(NPDR)[13.79±2.56 pg/m L(range 9.80-20.10) vs 13.63±2.71 pg/m L(range 10.20-20.20), P =0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [ 5. 37 ±1.74 pg/m L(range 2.85-8.65) vs 6.11±1.90 pg/m L(range3.13-9.41), P =0.293], or between control and DR groups[NPDR 6.11 ±1.90 pg/m L(range 3.13-9.41) vs control6.15±1.91 pg/m L(range 2.18-9.86); PDR(5.37±1.74 pg/m L(range 2.85-8.65) vs control 6.15 ±1.91 pg/m L(range2.18-9.86), P =0.808, P =0.264].·CONCLUSION: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity.
AIM: To report the association between melatonin levels in aqueous humor and serum, and diabetic retinopathy (DR) grade in type 2 diabetic patients. METHODS: Aqueous humor and plasma samples from 26 patients with DR (in nonproliferative and proliferative stages) and 14 control subjects were collected during cataract surgery after 6 pm Melatonin concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Melatonin levels were significantly higher in the aqueous humor of patients with proliferative diabetic retinopathy (PDR) [18.57 ± 2.67 pg (range 15.20-23.06) vs 13.63 ± 2.71 pg / m L (range 10.20-20.20), P = 0.0001], but not in those with nonproliferative retinopathy (NPDR) [13.79 ± 2.56 pg / m L -20.10) vs 13.63 ± 2.71 pg / m L (range 10.20-20.20), P = 0.961] compared to controls. There was decrement in the plasma melatonin level of patients with PDR, but no significant differences between the plasma melatonin levels of the study groups [5. 37 ± 1.74 pg / m (Range 2.85-8.65) vs 6.11 ± 1.90 pg / m L (range 3.13-9.41), P = 0.293], or between control and DR groups [NPDR 6.11 ± 1.90 pg / m L (range 3.13-9.41) vs (range 2.18-9.86), control 6.1.15 ± 1.91 pg / m L (range 2.18-9.86), PDR 5.37 ± 1.74 pg / m L (range 2.85-8.65) vs control 6.15 ± 1.91 pg / m L 0.808, P = 0.264] • CONCLUSION: Elevated melatonin levels in aqueous humor in PDR may indicate the level to be associated with DR severity.