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为探讨核糖核酸（ＲＮＡ）对血吸虫病肝纤维化兔血浆透明质酸（ＨＡ）和肝组织羟脯氨酸（ＨＹＰ）的影响，将５４只日本家兔随机均分为正常组、病理组、ＲＮＡ组。病理组和ＲＮＡ组每兔感染血吸虫尾蚴（１００±１）条，３０ｄ后用吡喹酮杀虫并对ＲＮＡ组用ＲＮＡ治疗，于用ＲＮＡ后第４０、７０、１００ｄ，每组随机选６只兔取血和肝供检测备用。用放射免疫方法测定血浆ＨＡ和紫外分光光度法测定肝组织ＨＹＰ含量。结果ＲＮＡ组ＨＡ于１００ｄ时（４．６６±１．３５）μｇ／ｍｌ，显著低于相同阶段的病理组（１０．１６±２．５２）μｇ／ｍｌ（Ｐ＜０．０１）；ＲＮＡ组ＨＹＰ于１００ｄ时（７．２４±１．２４）μｇ／ｍｇ肝粉，亦显著低于病理组相同阶段（１０．８５±１．７３）μｇ／ｍｇ肝粉（Ｐ＜０．０１）。表明ＲＮＡ对血吸虫病肝纤维化兔血浆ＨＡ和肝组织ＨＹＰ有下调作用。
In order to investigate the effects of RNA on the plasma HA and HYP in liver fibrosis rabbits with schistosomiasis, 54 Japanese rabbits were randomly divided into normal group, pathological group, RNA group. Each group of rabbits in the pathological group and RNA group were infected with (100 ± 1) cercariae of Schistosoma japonicum. After 30 days, the mice were treated with praziquantel and the RNA was treated with RNA. At the 40th, 70th and 100th days after RNA administration, 6 rabbits Rabbit blood and liver for testing spare. Radioimmunoassay was used to determine plasma HA and UV spectrophotometry to determine the content of HYP in liver tissues. Results The HA of the RNA group was significantly lower than that of the same stage at 10 days (4.66 ± 1.35) μg / ml (10.16 ± 2.52) μg / ml (P <0.01) The level of HYP on day 100 was (7.24 ± 1.24) μg / mg of liver meal, which was also significantly lower than that of pathological group (10.85 ± 1.73) μg / mg of liver meal (P <0.01). The results showed that RNA could downregulate the plasma HA and hepatic tissue HYP in schistosomiasis rabbits with liver fibrosis.